Coordination: | BOIX TORRAS, JACINT |
Academic year 2017-18 |
Subject name | MOLECULAR PATHOLOGY AND THERAPEUTICS | ||||||||
Code | 14700 | ||||||||
Semester | 1st Q(SEMESTER) CONTINUED EVALUATION | ||||||||
Typology |
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ECTS credits | 4 | ||||||||
Groups | 1GG | ||||||||
Theoretical credits | 0 | ||||||||
Practical credits | 0 | ||||||||
Coordination | BOIX TORRAS, JACINT | ||||||||
Department | CIENCIES MEDIQUES BASIQUES,MEDICINA,MEDICINA EXPERIMENTAL | ||||||||
Important information on data processing | Consult this link for more information. |
Teaching staff | E-mail addresses | Credits taught by teacher | Office and hour of attention |
BOIX TORRAS, JACINT | jacint.boix@mex.udl.cat | 1,2 | |
CANTI NICOLAS, CARLES | c.canti@mex.udl.cat | ,4 | |
DOLCET ROCA, F. XAVIER | dolcet@cmb.udl.cat | ,6 | |
ESQUERDA COLELL, JOSÉ ENRIQUE | josep.esquerda@mex.udl.cat | ,4 | |
MARTI LABORDA, ROSA MARIA | marti@medicina.udl.cat | ,2 | |
MATIAS-GUIU GUIA, XAVIER | xmatias@cmb.udl.cat | ,4 | |
RIBAS I FORTUNY, JUDIT | judit.ribas@mex.udl.cat | ,4 | |
SANCHIS MORALES, DANIEL | daniel.sanchis@cmb.udl.cat | ,4 |
CB1 Possessing knowledge and understanding that provide a basis or opportunity for originality in developing and / or applying ideas, often within a research context.
CB2 Being able to apply the acquired knowledge and have the ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study.
CB3 Being able to integrate knowledge and handle complexity, and formulate judgments based on information that was incomplete or limited, include reflecting on social and ethical responsibilities linked to the application of their knowledge and judgments.
CB4 Being able to communicate their conclusions, and the knowledge and rationale underpinning these, to specialist and non-specialist audiences in a clear and unambiguous.
CB5 Acquiring the learning skill to study in a self-directed and autonomous way.
CG1 Knowing how to select and apply different analytical methods molecular, biochemical, cellular, genetic and phenotypic for the diagnosis and study of disease.
CG4 Capacity for critical and creative thinking with your work and that of other researchers.
CE3 Identifying and assessing the implications of the phenomenon of cell death in the pathogenesis of multiple diseases and the therapeutic rational basis that provides.
CE4 Recognizing the high performance techniques (high throughput) and the use of bioinformatics tools for data analysis.
CT1 Having a correct oral and written expression
CT4 Respect the fundamental rights of equality between men and women, to the promotion of human rights and the values of a culture of peace and democratic values
The molecular mechanisms that cause the pathological phenotypes in the cells and their pharmacological modulation are the main subject of this course. Physical agents like radiation, chemical or biological ones like mutagens, viral infections, etc. converge in generating degenerative phenotypes that will precede cell death or, alternatively, oncogenic transformation characterized by proliferative expansion, loss of cell differentiation and resistance to hypoxia and therapy. Cell death by apoptosis, autophagy and, even, necrosis occur by an ordered activation of molecular mechanisms. Tumoral progression, cell heterogeneity in neoplasia, tissue invasion and metastasis are the result of specific molecular disruptions. As an example, the dysfunctions in the expression regulatory networks defined by microRNAs (miRNAs). A better understanding of these mechanisms and events will allow the identification of therapeutic targets and strategies, diagnostic resources and valuable prognostic parameters.
Lectures (Topics), Seminars, Scientific conference
1. LECTURES
TOPIC 1. CELL NECROBIOLOGY
(Prof. J. Boix)
TOPIC 2. CASPASES
(Prof. J. Boix)
TOPIC 3. THE REGULATION OF CASPASE ACTIVATION
(Prof. J. Boix)
TOPIC 4. THE BCL-2 FAMILY OF PROTEINS
(Prof. J. Boix)
TOPIC 5. AUTOPHAGY
(Prof. C. Cantí)
TOPIC 6. MECHANISMS OF CANCER INITIATION
(Prof. X. Matias-Guiu)
TOPIC 7. MOLECULAR MECHANISMS FOR CANCER PROGRESSION
(Prof. X. Dolcet)
TOPIC 8. MODELING CANCER IN VIVO AND IN VITRO
(Prof. X. Dolcet)
TOPIC 9. STEM CELLS IN CANCER
(Prof. X. Dolcet)
2. SEMINARS
SEMINAR 1. APOPTOSIS AND VIRAL PATHOGENESIS
(Prof. J. Boix)
SEMINAR 2 and 3. CELL DEATH AND MOTONEURON DISEASE
(Prof. J. E. Esquerda)
SEMINAR 4 and 5. CELL DEATH IN CARDIAC DISEASE
(Prof. D. Sanchis)
SEMINAR 6. CYTOPROTECTIVE AUTOPHAGY
(Prof. C. Cantí)
SEMINAR 7. MOLECULAR PATHOLOGY OF MELANOMA
(Prof. R. M. Martí)
SEMINAR 8. MOLECULAR PATHOLOGY OF ENDOMETRIAL CARCINOMA
(Prof. X. Matias-Guiu)
SEMINAR 9. MICRORNA (miRNA)
(Prof. J. Ribas)
SEMINAR 10. MOLECULAR TARGETS IN ANTI-TUMOR THERAPY
(Prof. X. Matias-Guiu / Prof. Boix)
3. CONFERENCE
Specific and general bibliography will be provided. Students will get PDF files related to the subjects approached in the course by connecting to their master folders in the UdL network.