Teaching staff	E-mail addresses	Credits taught by teacher	Office and hour of attention
JOVE FONT, MARIONA	mariona.jove@udl.cat	6

Knowledge goals:

Understanding the social dimension of the aging population.
Demonstrate that the biological elements involved in the aging process are knowed.
Understanding the close relationship between the structure and function at all levels of organization of living as a determinant of longevity beings.
Discerning and understanding how the different nutritional interventions can modify the aging process.

Capability goals: Students who pass the subject must be able to:

1. Use oral and written communication skills in the most appropriate and effective way.

2. Think clearly and critically, fusing experience, knowledge and reasoning.

3. Identify, interpret and solve problems effectively.

Specific skills

Knowing the reactive oxigen species generators and antioxidant defenses systems.Understanding the mechanisms of cellular response to stress, at molecular level.
Understanding the molecular basis of physiological aging and associated pathologies.
Knowing the effects of specific nutritional interventions on the oxidative stress and the aging process.
Knowing the nutraceutical foods that contain ingredients with specific effect on oxidative stress and the aging process and related diseases.

Transversal skills

Nutraceutics and aging it must encourage and promote the acquisition of transversal competences that are intrinsically related to it and provide students:

Oral and written expression
To Use information technology and communication and technology platforms
Significant domain of foreign language
Using critical and scientific thinking

Emtrepreneurship and professional environment

Lesson 1. Aging process

The historical perspective. Social dimension of the aging population. Definition of aging. Average longevity versus maximum longevity. Aging theories.

Lesson 2. Nutraceutics

Definition. Classification. Properties, structure and function. Bioavailability study and bioavailability.

Lesson 3. Oxidative stress

The natural history of oxygen. Oxygen toxicity. The origin of the theory of free radicals.

Lesson 4. Reactive oxigen species

Chain mitochondrial electron transport. The generation of reactive oxygen species. physiological mechanisms that influence the production of ROS.

Lesson 5. Antioxidant cellular systems

Enzymatic antioxidants. Nonenzymatic antioxidants. Antioxidants repair systems, replacement or detoxification.

Lesson 6. Oxidative stress effects

Reactive molecular intermediates of first and second generation. Endogenous oxidative damage on lipids, proteins and DNA.

Lesson 7. Longevity and oxidative stress

Interspecies comparative studies. Injury and endogenous antioxidant levels in longevity. Endogen oxidative damage in aging. Structural cellular components resitants to oxidative damage.

Lesson 8. Nutritional interventions

Caloric restriction and oxidative stress. The mechanism of caloric restriction. Caloric restriction and aging. Protein restriction, oxidative stress and aging. Methionine restriction, oxidative stress and aging.

Lesson 9. Aging related pathologies

Neurodegenerative diseases: Alzheimer and Parkinson. Study on the effect of nutrition on aging and associated pathologies.

Lesson 10. Nutraceutical foods and aging

Nutraceuticals and aging. Aging related pathologies and nutraceutical use and effects .

To achieve the objectives and acquire the powers conferred upon the following activities are scheduled:

Classroom teaching : They are made with all students. They are intended to give an overview of the thematic content of the subject highlighting those aspects that are going to serve them in their training.

Seminars : They are conducted with all students and attendance is mandatory. The seminars are aimed at students to apply theoretical concepts and deepen with the most important and most complex aspects of the issues.

Specific work: Bibliographic research work with Professor monitoring will be conducted and will be presented at the end of the course. The works are aimed at students to apply the theoretical concepts and deepen with some aspect of the subject complex through also the implementation of the transversal competences.

Day
1	introducció
2	Tema 1.Envelliment
3	Seminari 1.
4	Tema 2. Nutriceutics
5	Seminari 2.
6	Tema 3.Estrès oxidatiu
7	Tema 4. ROS I
8	Tema 4. ROS II
9	Tema 5. Antioxidants
10	Tema 6. Efectes dels ROS
11	Seminari 3.
12	Seminari 4.
13	Tema 7. Longevitat
14	Estudi
15	Tema 8. CR
16	Tema 8. MetR
17	SEminari 5.
18	SEminari 6.
19	Tema 9. Patologies
20	Seminari 7.
21	Seminari 8.
22	Seminari 09.
23	Seminari 10.
24	Seminari 11.
25	Presentació oral treballs
26	Presentació oral treballs
27	Presentació oral treballs
28	Presentació oral treballs
29	Presentació oral treballs
30	Presentació oral treballs

Exams 58%.

Two exams (29% each) including all the theoretical part. The exams will consist of multiple choie questions and short-answer questions.

To pass the course, students will have to pass this appraisement with a minimum of 50% of the value of this section.

Failure to attend an examination for fully justifiable reasons, will be communicated during the same week of the announcement of the exam. Date and timetable agreed between the teacher and student for the exam within the same week of the call will be sought.

Seminars 17%

The seminar is conducting reviews of the literature discussing scientific articles related to the topics discussed in class. Comments will be made and discussed different aspects the seminar. One of the seminars will try to conduct a debate on an issue related to any topic of the subject.

The evaluation is as follows:

- Assistance to seminars, implementation of activities, active participation in the comments of the different scientific papers, participation and conduct of the debate.

- Compulsory attendance at all seminars. Two excused absences are allowed.

Specific work 25%

Students will have to do a bibliographic research by some topics selected by the teacher, submit a written report, and will have to present it orally in front of the class.

The duration of the presentation will be 20 minutes plus 5 or 10 minutes of questions.

Each student will have to do at least 5 questions and / or comments along attendance at presentations of the work from their classmates.

The evaluation will be as follows:

- Written work (introduction, content, conclusions, literature) 35%

- Oral presentation (introduction, content, conclusions) 35%

- Resolution of Questions 5%

- If the student fails to attend more than two presentations of the work of their peers 10% of the note is subtracted.

- Exam to evaluate the knowledge learned from all the specific works of the classmates.

Halliwell, B. Free radicals in biology and medicine. Publicació Oxford; New York: Oxford University Press, 2007 Edición 4th ed

Masoro, Edward J Caloric restriction: a key to understanding and modulating aging. [Recurs electrònic] : a key to understanding and modulating aging / Edward J. Masoro Publicació Amsterdam ; Boston : Elsevier, 2002 Edición 1st ed

Antioxidant and redox regulation of genes [Recurs electrònic] / edited by Chandan K. Sen, Helmut Sies, Patrick A. Baeuerle Publicació San Diego : Academic Press, 2000

Handbook of the biology of aging [Recurs electrònic] / editors, Edward J. Masoro and Steven N. Austad Publicació Amsterdam ; Boston : Elsevier Academic Press, 2006 Edición 6th ed.

McDonald, RB. Biology of Aging. Edited by Garland Science, Taylor & Francis Group, LLC., 2014.

Enlazes de interés

www.freemedicaljournals.com

www.scopus.com

www.ncbi.nlm.nih.gov

www.nutricion.org

www.nal.usda.gov/fnic

Revistas

Age

Ageing research review

Aging cell

Biogerontology