Coordinació: | PAMPLONA GRAS, REINALDO RAMON |
Any acadèmic 2019-20 |
Denominació | ESTRÈS OXIDATIU I ANTIOXIDANTS | ||||||||||||
Codi | 14706 | ||||||||||||
Semestre d'impartició | 1R Q(SEMESTRE) AVALUACIÓ CONTINUADA | ||||||||||||
Caràcter |
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Nombre de crèdits assignatura (ECTS) | 4 | ||||||||||||
Tipus d'activitat, crèdits i grups |
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Coordinació | PAMPLONA GRAS, REINALDO RAMON | ||||||||||||
Departament/s | MEDICINA EXPERIMENTAL | ||||||||||||
Distribució càrrega docent entre la classe presencial i el treball autònom de l'estudiant | Teoria:
Hores dedicades a l'activitat formativa: 30; Porcentatje de presencialitat: 100% Assistència a conferències científiques i pràctiques orals comunicatives: Hores dedicades a l'activitat formativa: 10; Porcentatje de presencialitat: 100% Treball autònom: Hores dedicades a l'activitat formativa: 60; Porcentatje de presencialitat: 0% | ||||||||||||
Informació important sobre tractament de dades | Consulteu aquest enllaç per a més informació. | ||||||||||||
Idioma/es d'impartició | Català
Castellà Anglès | ||||||||||||
Distribució de crèdits | 1. Oxidative Stress Biology (1,4 crèdits)
2. Oxidative Stress in Medicine (1,0 crèdits) 3. Antioxidants and Nutrition (0,6 crèdits) 4. Seminars and other activities (1,0 crèdits) |
Professor/a (s/es) | Adreça electrònica professor/a (s/es) | Crèdits impartits pel professorat | Horari de tutoria/lloc |
AYALA JOVE, MARIA VICTORIA | victoria.ayala@udl.cat | ,6 | |
BOADA PALLAS, JORDI | jordi.boada@udl.cat | ,6 | |
CABISCOL CATALA, ELISA | elisa.cabiscol@udl.cat | ,6 | |
PAMPLONA GRAS, REINALDO RAMON | reinald.pamplona@udl.cat | ,4 | |
PORTERO OTIN, MANUEL | manuel.portero@udl.cat | ,4 | |
ROS SALVADOR, JOAQUIN | joaquim.ros@udl.cat | ,6 | |
SERRANO CASASOLA, JOSÉ CARLOS ENRIQUE | josecarlos.serrano@udl.cat | ,2 | |
TAMARIT SUMALLA, JORDI | jordi.tamarit@udl.cat | ,6 |
To define and identify free radicals
To recognize the chemistry and biological sources of free radicals and other reactive molecular species
To define the concept of cellular stress
To know, at molecular level, the cellular defense mechanisms in front of oxidative stress
To characterize the free radical-derived molecular damage
To know methods for the detection and quantification of both free radicals and biomarkers of molecular damage
To identify and characterize antioxidant systems, locations and mechanisms of action
To recognize free radical biological effects and adaptive cellular mechanisms
To identify and recognize xenobiotics mechanisms of action and their nutritional and medical implications
To recognize the role of free radiclas in pathological processes
To identify natural sources of antioxidants and its role in human nutrition
To adquire skills to analyze and communicate the scientific information
COMPETENCES
CB1 Possess knowledge and understanding that provide a basis or opportunity for originality in developing and / or applying ideas, often within a research context
CB2 Being able to apply the acquired knowledge and have the ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study
CB4 Being able to communicate their conclusions, and the knowledge and rationale underpinning these, to specialist and non-specialist audiences in a clear and unambiguous
CG1 Knowing how to select and apply different analytical methods at the molecular, biochemical, cellular, genetic and phenotypiclevel for the diagnosis and study of the diseases.
CG4 Capacity for critical and creative thinking with their own work and that of other researchers
CE9 That the students can identify the effects of oxidative stress, the cellular mechanisms of stress response and being able to apply the methods of detection and quantification of free radicals and molecular biomarkers of injury
CT1 Having a correct oral and written expression
1. Oxidative Stress Biology (14 hours)
An introduction to oxygen toxicity and reactive species (1h)
The chemistry of free radicals and related ‘reactive species’ (2h)
Oxidative-derived molecular damage (3h)
Measurement of free radicals and molecular damage (3h)
Endogenous antioxidant defences (3h)
Cellular responses to oxidative stress: adaptation and repair (2h)
Cellular redox signaling (2h)
2. Oxidative Stress in Medicine (10 hours)
Oxidative stress, aging and longevity (2h)
Oxidative stress in human diseases (8h)
3. Antioxidants and Nutrition (6 hours)
Diet-derived antioxidant defences (3h)
Antioxidants in human nutrition (3h)
4. Seminars and other activities (10h/alumne)
Seminars: 4 groups (n = 3 x group)
Laboratory respirometry: 2 groups
Discussion of scientific papers: An article presentation x group for each field (1.OSB; 2. OSM; 3. A&N). Presentation duration: 20 min.
Conferences: According to the IRB ‘Friday Seminars’
El proceso de enseñanza-aprendizaje se llevará a cabo mediante:
1 Clases magistrales
2 Conferencias científicas
3 Debate dirigido: análisis y discusión de trabajos científicos
4 Clases prácticas
El proceso de enseñanza-aprendizaje se llevará a cabo mediante:
1 Clases magistrales
2 Conferencias científicas
3 Debate dirigido: análisis y discusión de trabajos científicos
4 Clases prácticas
Two intermediate evaluation activities for theoretical contents (30%+30%), 1 evaluation activity for scientific seminars (presentation, analysis skills and discussion) (30%), and 1 evaluation laboratory activity (10%).
Textbooks
Free Radicals in Biology and Medicine. Editat per Halliwell B i Gutteridge JMC. Oxford University Press, New York, 2007.
Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. Isabella Dalle-Donne (Editor), Andrea Scaloni (Editor), D. Allan Butterfield (Editor) (2006)
Protein Carbonylation: Principles, Analysis and Biological Implications. Joaquim Ros (Editor). Wiley. 2017
Internet Resources