Català Castellano
DEGREE CURRICULUM
MOLECULAR PATHOLOGY AND THERAPEUTICS
Coordination:
BOIX TORRAS, JACINT
Academic year 2019-20
DEGREE CURRICULUM: MOLECULAR PATHOLOGY AND THERAPEU... 2019-20

Subject's general information
Subject nameMOLECULAR PATHOLOGY AND THERAPEUTICS
Code14700
Semester1st Q(SEMESTER) CONTINUED EVALUATION
Typology
DegreeCourseCharacterModality
Master's Degree in Biomedical Research1COMMONAttendance-based
Course number of credits (ECTS)4
Type of activity, credits, and groups
Activity typeTEORIA
Number of credits4
Number of groups1
CoordinationBOIX TORRAS, JACINT
DepartmentEXPERIMENTAL MEDICINE
Teaching staffE-mail addressesCredits taught by teacherOffice and hour of attention
BOIX TORRAS, JACINTjacint.boix@mex.udl.cat1,4
DOLCET ROCA, FRANCESC XAVIERdolcet@cmb.udl.cat,6
ESQUERDA COLELL, JOSÉ ENRIQUEjosep.esquerda@mex.udl.cat,4
MARTI LABORDA, ROSA MARIAmarti@medicina.udl.cat,2
PROFESSOR PENDENT ASSIGNAR,4
RIBAS FORTUNY, JUDITjudit.ribas@mex.udl.cat,6
SANCHIS MORALES, DANIELdaniel.sanchis@cmb.udl.cat,4
Learning objectives
  1. The development of an integrative and molecular view of the human cell in disease.
  2. The identification of cell death phenotypes and other degenerative or infectious cytophatic traits.
  3. The description of molecular entities that regulate and execute apoptosis and other types of cell death.
  4. The molecular characterization of the tumor cell phenotype, the cell heterogeneity in neoplasia and the invasive and metastatic potential.
  5. The understanding of the tumor resistance to hypoxia and therapy mechanisms.
  6. The performance of translational approaches, diagnostic, prognostic or therapeutic based on the molecular mechanisms stated before.
Significant competences

CB1 Possessing knowledge and understanding that provide a basis or opportunity for originality in developing and / or applying ideas, often within a research context.

CB2 Being able to apply the acquired knowledge and have the ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their field of study.

CB3 Being able to integrate knowledge and handle complexity, and formulate judgments based on information that was incomplete or limited, include reflecting on social and ethical responsibilities linked to the application of their knowledge and judgments.

CB4 Being able to communicate their conclusions, and the knowledge and rationale underpinning these, to specialist and non-specialist audiences in a clear and unambiguous.

CB5 Acquiring the learning skill to study in a self-directed and autonomous way.

CG1 Knowing how to select and apply different analytical methods molecular, biochemical, cellular, genetic and phenotypic for the diagnosis and study of disease.

CG4 Capacity for critical and creative thinking with your work and that of other researchers.

CE3 Identifying and assessing the implications of the phenomenon of cell death in the pathogenesis of multiple diseases and the therapeutic rational basis that provides.

CE4 Recognizing the high performance techniques (high throughput) and the use of bioinformatics tools for data analysis.

CT1 Having a correct oral and written expression

CT4 Respect the fundamental rights of equality between men and women, to the promotion of human rights and the values of a culture of peace and democratic values

 

Subject contents

The molecular mechanisms that cause the pathological phenotypes in the cells and their pharmacological modulation are the main subject of this course. Physical agents like radiation, chemical or biological ones like mutagens, viral infections, etc. converge in generating degenerative phenotypes that will precede cell death or, alternatively, oncogenic transformation characterized by proliferative expansion, loss of cell differentiation and resistance to hypoxia and therapy. Cell death by apoptosis, autophagy and, even, necrosis occur by an ordered activation of molecular mechanisms. Tumoral progression, cell heterogeneity in neoplasia, tissue invasion and metastasis are the result of specific molecular disruptions. As an example, the dysfunctions in the expression regulatory networks defined by microRNAs (miRNAs). A better understanding of these mechanisms and events will allow the identification of therapeutic targets and strategies, diagnostic resources and valuable prognostic parameters.

Methodology

Lectures (Topics), Seminars, Scientific conference
See development plan for further information

 

Development plan

1. LECTURES

TOPIC 1. CELL NECROBIOLOGY

(Prof. J. Boix)

TOPIC 2. CASPASES

(Prof. J. Boix)

TOPIC 3. THE REGULATION OF CASPASE ACTIVATION

(Prof. J. Boix)

TOPIC 4. THE BCL-2 FAMILY OF PROTEINS

(Prof. J. Boix)

TOPIC 5. AUTOPHAGY

(Prof. J. Ribas)

TOPIC 6. MECHANISMS OF CANCER INITIATION

(Prof. X. Matias-Guiu)

TOPIC 7. MOLECULAR MECHANISMS FOR CANCER PROGRESSION

(Prof. X. Dolcet)

TOPIC 8. MODELING CANCER IN VIVO AND IN VITRO

(Prof. X. Dolcet)

TOPIC 9. STEM CELLS IN CANCER

(Prof. X. Dolcet)

 

2. SEMINARS

SEMINAR 1. APOPTOSIS AND VIRAL PATHOGENESIS

(Prof. J. Boix)

SEMINAR 2 and 3. CELL DEATH AND MOTONEURON DISEASE

(Prof. J. E. Esquerda)

 SEMINAR 4 and 5. CELL DEATH IN CARDIAC DISEASE

(Prof. D. Sanchis)

SEMINAR 6. EXPERIMENTAL APPROACHES TO AUTOPHAGY

(Prof. J. Ribas)

SEMINAR 7. MOLECULAR PATHOLOGY OF MELANOMA

(Prof. R. M. Martí)

SEMINAR 8. MOLECULAR PATHOLOGY OF ENDOMETRIAL CARCINOMA

(Prof. X. Matias-Guiu)

SEMINAR 9 and 10. THE MODULATION OF CELL DEATH WITH DRUGS IN THE CONTEXT OF HUMAN THERAPEUTICS 

(Prof. J. Boix)

 

3. CONFERENCES

 

Evaluation
Bibliography

Specific and general bibliography will be provided. Students will get PDF files related to the subjects approached in the course by connecting to their master folders in the UdL network.

PDF